Protein models and the PDB

A post by Deepak alerts that the PDB will no longer be accepting computational models of protein structures as of this October, and notes the pressing need for a peer-reviewed knowledgebase of protein models to exist alongside the PDB. The field of “structural genomics” has envisaged a marriage of experimental and theoretical determinations since its beginnings in 1998, but since then one gets the impression that the US-funded Protein Structure Initiative (PSI) has been sidetracked by the difficulties involved in experimentally determining protein structures in a number that approaches its initial somewhat optimistic forecasts. It is encouraging to see via these press releases that computational modeling is still within the realm of the PSI. Large scale funding for protein structure modeling such as this may deliver the kind of quality protein model databases that are needed in the light of the decision of the PDB.

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